The history of quinolones.- Structure-activity relationships of quinolones.- Epidemiology and mechanisms of resistance.- Improved safety profile of newer fluoroquinolones.- Pharmacokinetics and pharmacodynamics (PK/PD) of fluoro-quinolones: tools for combating bacteria and preventing resistance.- Fluoroquinolones in urinary tract infection.- The quinolones and sexually transmitted infections.- Gastrointestinal and intraabdominal infections.- The quinolones in otitis media and upper respiratory infections.- Quinolones in pneumonia.- Fluoroquinolones for the treatment of respiratory tractinfections other than pneumonia.- Quinolones for the treatment of skin, soft tissue, bone andprosthetic joint infections.- The role of fluoroquinolones in the therapy and prophylaxisof neutropenic patients with cancer.- Less usual indications: Mycobacterial, Brucella, Yersinia,Francisella and other infections.- The quinolones: future prospects.
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